Commuters have been stranded for hours in the gridlock on the Lagos-Ibadan expressway outward Berger/Ojota.
The ripple effect of traffic on that axis has trickled into other areas of the city.
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There are reports that the gridlock was caused by the collision of two tankers and an articulated vehicle at about 2:00am in Kara.
Emergency responders have been at the scene of the incident cleaning up spilled content from the tankers to avoid a fire outbreak.